According to the web site drugs.com, diphenhydramine is on the list of drugs that interact with Zyrtec. Diphenhydramine is a central nervous system depressor, and use of it with Zyrtec could cause drowsiness. Here is the warning statement that drugs.com has posted:
In the event that they are used together, patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
Another web site, allergies.emedtv.com, has a more detailed warning:
Combining Zyrtec with other medications that cause drowsiness could increase the risk of serious problems, such as confusion, memory loss, or difficulty breathing. Serious reactions could also occur.
Webmd.com also cautions against using Zyrtec and any other antihistamine together because both cause drowsiness. The fear is that when used together, these drugs might cause your central nervous system to shut down.
I would take your advice seriously. I, too, have a lot of allergies and have to be careful about drug interactions. You might try seeing a doctor who specializes in treating allergies.
I hope this helps you. Good luck!
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