Can you please help me write an essay on the topic "Lonliness" from "Of Mice and Men" in my own words?Thank you very much for all your help.

I think that in examining the characters in the novel, you might be able to derive some valuable information about the topic of loneliness.  I would start off with George.  Where is he lonely?  How can we see loneliness in his heart and spirit?  Certainly, you can start off with the ending and having to put down Lennie in the face of the lynch mob.  Pay attention to how Steinbeck describes this and the feelings George experiences afterwards.  It would be appropriate to argue that Lennie and George always travelled together and there was a relationship between the two of them predicated on George's care (There are plenty of quotes where George says this, where Lennie believes this, and where Steinbeck asserts this.)  If this is true, when Lennie is gone, George must experience a physical and emotional sense of emptiness.  Finally, I would suggest that George is also lonely because his hopes and faith that things will work out for him are dashed significantly.  The weakness of Curly's wife and the cruelty of Curly and the mob prove to George that social harmony is not possible in the life he is leading.  This contributes to a sense of loneliness.  I think you could also extrapolate this to talking about how George is animated and inspired by his dreams.  Both big and small, owning a farm with Lennie or skipping work to go to a ball game, George believes in the motivating power and the successful element of his dreams.  When they are dashed, when he does not make it big, and when success is not evident, there might be a feeling of loneliness here, too.  When dreams are all one has and they are dashed, despair and abandonment are quite natural feelings.  You can find some evidence and thoughts from the book in this realm, as well.